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(2015) 309:C16978

doi: 10.3390/cells11233782

Another dominant gene, VPS35, involved in endosomal-lysosomal sorting, has been linked to PD through whole-exome sequencing studies [162]

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These findings suggest a feedback loop were in KU-57788-induced DRP1 activation enhances mitochondrial fission and fragmentation, accompanied by the activation of the NRF2/SLC7A11/GSH axis to neutralize ROS and protect ATC cells from KU-57788 cytotoxicity