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Experimental hypothyroid models, including T3/T4 withdrawal and TH receptor (TR/) knockout mice, show spontaneous hepatic collagen accumulation and elevated expression of pro-fibrotic genes, confirming that TH deficiency alone can drive ECM remodeling

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Frequent loss of heterozygosity (LOH) on chromosome 3p in lung tumors was associated with low GPx1 enzyme activities, which may affect the prognosis of lung cancer patients [86]