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Slow titration schedules, typically adding one dose increment every four weeks, appear to reduce dropout rates due to gastrointestinal side effects

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doi: 10.1038/s41572-020-0184-y 3 BrandtFThvilumMHegedsLBrixTH

Sublingual administration bypasses the liver entirely, delivering 6085% of the dose to systemic circulation within 2030 minutes

Energy metabolism relies on the continuous exchange of free electrons [77]