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Patients should continue evidence-based lipid-lowering therapy as recommended by NICE guidelines whilst considering GLP-1 therapy for its licensed indications
Angiotensin-converting enzyme degrades Alzheimer amyloid -peptide (A)
Fe-S clusters are vital cofactors for various mitochondrial enzymes, including those involved in the electron transport chain (ETC)
Thus, the loss of intracellular GSH in the presence of active generation of hydroperoxy-phospholipids could occur through several active mechanisms, including formation of GSH, export of GSSG, inadequate replenishment of GSH, or insufficient levels of GSSG reductase, each directly or indirectly dependent on the generation of hydroperoxy-phospholipids
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