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Freezing may cause structural damage, especially in liposomal or liquid forms

Weng Y, Song Q, Zhou Y, Zhang L, Wang J, Chen J et al (2011) Immobilization of selenocystamine on TiO2 surfaces for in situ catalytic generation of nitric oxide and potential application in intravascular stents

Conclusion: Prourokinase demonstrated no superiority over alteplase, with the exception of a slight advantage in early NIHSS score improvement, and exhibited an acceptable and comparable safety profile

They are very gentle and do their best to give the patients the expected results