However, cases were assigned as non-overdose by an expert committee if there was no history of overdose and a non-toxic plasma paracetamol concentration (PPC), meaning that some of these cases may in fact have been concealed overdoses if a history of overdose was not given and enough time had elapsed for PPC to become undetectable [26]
Gardiner C, Weakley J, Burke L, et
These effects may be optimally stimulated at lower concentrations where the body interprets the signal as a gentle prompt rather than an emergency
the FDA prescribing information outlines pancreatitis and kidney warnings
Transl Psychiatry 11 , 15 (2021)
The FDA notes that compounded drugs are not FDA-approved, meaning the agency does not review compounded versions for safety, effectiveness, or quality before they are marketed or dispensed