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In Conclusion Until there is more evidence-based research on the impact of GLC-1 receptor agonists on anesthesia, specifically conscious sedation, DOCS Education recommends a medical consult with the patients PCP or endocrinologist, and absent the strong recommendation to the contrary from their prescribing physician, have the patient withhold their weekly injectable GLP-1 receptor antagonist one week before sedation, and their daily GLP-1 receptor agonist on the day of the sedation appointment, and be NPO 6 hours before the appointment as usual

This is especially true with the new class of drugs being used for weight loss

1% acetic acid is an acceptable alternative

Every single vial must be validated through rigorous independent testing

Is the powder still dry and compact, or has it shifted or clumped (suggesting moisture exposure)

Well known limitations, such as incomplete data recording or the presence of reporting biases can impact the reliability of these findings