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Parasite and disease control is critically dependent on interferon (IFN)-producing type 1 T helper (Th1) cells and macrophages expressing type 2 nitric oxide synthase (NOS2), whereas non-healing, chronic CL has been linked to the expansion of interleukin (IL)-4-secreting Th2 cells, IL-10-producing CD4 + T cells and the expression of arginase 1 (ARG1) (Bogdan et al, 2024

Contributing to the occlusion of sick arteries can worsen the condition, potentially leading to thrombosis (170)

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Biswasroy P, Pradhan D, Haldar J, Kar B, Ghosh G, Rath G

In humans, it has been observed that the oral administration of Mg 2+ significantly reduced PTS (Attias et al., 2+ is well-tolerated although there are some dose-dependent side effects such as nausea, diarrhea, stomachache, headache, tinnitus, and dizziness, which appear when used at high concentrations (Attias et al., 2006