Andy Galpin: Optimal Nutrition & Supplementation for Fitness 03:04:02 Tool: Sodium Bicarbonate From Episode Dr
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Cagrilintide vs tirzepatide (Mounjaro/Zepbound) Mechanism: Cagrilintide: Amylin agonist Tirzepatide: Dual GIP/GLP-1 agonist Both novel approaches Weight loss: Cagrilintide: 10-12% monotherapy Tirzepatide: 15-22% monotherapy Tirzepatide superior as single agent Administration: Both: Weekly subcutaneous injection Both: Similar convenience Side effects: Cagrilintide: Strong GI effects Tirzepatide: Moderate GI effects Similar overall profile Approval status: Cagrilintide: Investigational Tirzepatide: FDA approved Tirzepatide available now Cost (when both available): Likely similar ($1,000-1,500/month) Both premium weight loss options Verdict: Currently, tirzepatide better choice (approved, superior weight loss)
Article Update History: Updated: April 26, 2025 Updated: June 06 2024 Originally Published: October 31, 2022 Comments Hi Brendan
The medications work as a GIP and GLP-1 receptor agonists, activating the hormone receptors and working to slow digestion and, in turn, increase satiety and reduce food cravings
Clinical trials have demonstrated that Ozempic significantly reduces HbA1c levels and body weight compared with placebo and several active comparators
