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It eliminates confounding variables and allows the true effects of the compound to be observed

305 The probiotic Lactobacillus reuteri (Lr) within melanoma promotes the local generation of IFN by CD8 + T cells through the release of its tryptophan breakdown metabolite, indole-3-aldehyde (I3A), thus enhancing ICI efficacy

It is produced by specialized cells called melanocytes and plays an important biological role

Some patients experience constipation due to prolonged transit time, while others may develop diarrhea, possibly related to changes in gut motility patterns or alterations in intestinal fluid handling

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