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While definitive causal reduction in cancer risk with GLP-1 therapies is not established, the cardiovascular and metabolic benefits of significant weight loss may outweigh theoretical cancer concerns for many patients

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Notably, in patients with obvious proteinuria, the levels of ACSL4 , MDA, and ROS were significantly increased, while the levels of GPX4 were markedly reduced ( ALOX15 ) and HMOX1 were significantly upregulated in the serum of DKD patients and closely related to inflammatory markers ( Epigenetic regulatory factors have also become potential biomarkers

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