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The therapeutic era of peptides began in 1921 with the discovery of insulin, a breakthrough that revolutionized diabetes and helped establish biologic therapies in medicine Since then, peptide hormones like oxytocin and human growth hormone (GH) have entered clinical use, and glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide are now widely prescribed for obesity and metabolic diseaseconditions increasingly recognized for their effect on orthopaedic outcomes

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Proc Natl Acad Sci 107:87888793 Wu C, Chen L, Jin S, Li H (2018) Glutaminase inhibitors: a patent review

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Why Site Rotation Matters For long-term injection success, site rotation is critical