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Moreover, in another study, L-theanine effectively regulated the secretion of cytokines such as IFN-, IL-2, IL-4, IL-10, IL-12, and TNF- except for IL-6 by activating the mRNA and protein expression of Ras-related protein Rap-1A (Rap1A), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), and farnesyl diphosphate synthase (FDPs) in the mevalonate synthesis pathway of rat splenic lymphocytes (93)

If weight creeps beyond 5% above the lowest recorded weight on therapy, restarting is clinically appropriate

If you plan to resume, restart at the full dose rather than titrating back up, since the break period allows receptor resensitization