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While the use of gonadotropins is approved for treatment of hypogonadotropic hypogonadism, their possible benefit in men with infertility related to idiopathic sperm abnormalities is still under investigation

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For instance, metabolomic analysis of plasma from metformin-treated individuals with high blood glucose levels and those with low blood glucose levels revealed a microbial metabolite, imidazole propionate, as a negative regulator of metformin efficacy in humans (Koh et al., 2020)

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