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For researchers who are also competitive athletes, note that compounds not approved for human use can fall under broad anti-doping categories even where not specifically named

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Certain disorders or health conditions like Crohns disease, celiac disease, or other intestinal disorders can mean it is more difficult for the body to absorb B12 from the food you eat

This can lead to pernicious anemia, a specific form of anemia

PubMed ID: 11713213 Ng FM et al

However, individuals with absorption disorders may require significantly higher doses to achieve therapeutic levels