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Both are problematic

As results were already strongly statistically significant with these initial values, we did not add additional mice to the study under the principle of reduction in animal experiments [34]

Another study on rats with OA showed that GLP-1R activation can reduce cartilage inflammation through the protein kinase A/cAMP response element-binding protein pathway[14]

62 Liraglutide has an arginine at position 34 (GLP-1(7-37)) that is lysine, and its lysine at position 26 connects to a 16-carbon palmitic acid side chain linked by glutamic acid

Additionally, Semaglutide GLP-1 slows gastric emptying, which occurs when stomach contents move into the small intestine as part of digestion

Our data suggests a couple of key reasons