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First, it has been recommended to control or modify the patient-related factors, site-related factors and surgical factors for optimal clinical outcomes

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However, there is increasing evidence that MSCs administered intravenously are easily trapped in several tissues (lung, liver or spleen) due to their larger size and adhesive nature (expression integrin CD49f or CD49d) as a result about 2% of cells delivered reac the target lesion site [16,54]