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Stevenson EJ, Astbury NM, Simpson EJ, Taylor MA, Macdonald IA

[DOI] [Google Scholar] 17

In brief, indoleamine 2,3-dioxygenase (IDO) activity is increased during inflammation, leading to increased conversion of tryptophan to kynurenine, reducing substrate availability for serotonin synthesis

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In addition, application of the P-15-containing graft substitutes was found to accelerate the process of early bone formation response but not the long-term effect [129, 131, 135]