Understanding how semaglutide works provides important context when evaluating its safety profile, including potential effects on organ systems such as the liver
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Research suggests it may increase acetylcholine levels*
In contrast, compared to placebo, semaglutide resulted in a 59% improvement in MASLD and an improvement in liver fibrosis, which slowed the progression of the disease [130]
Despite the promising potential of GLP-1 RAs, it is essential to conduct further clinical studies to confirm their long-term efficacy and safety in patients with HFpEF