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Miao, R

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About 7% of patients using tretinoin 0.02%, compared to less than 1% of the control patients, had sufficiently severe local irritation to warrant short-term use of mild topical corticosteroids to alleviate local irritation

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gasseri enrichment is a key mechanism, future studies using germ-free models or specific Lactobacillus -depletion strategies are needed to confirm its indispensability for QCHSs full therapeutic effect