Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase
The SURMOUNT-1 trial (tirzepatide, similar population) reported average weight loss up to about 20.9 percent at the highest dose over 72 weeks (Jastreboff AM, et al
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Until those data mature, clinicians should frame Wegovys MASH indication as evidencesupported for histologic response but still under confirmatory evaluation for hard liver outcomes. Safety profile and risk management Safety considerations for Wegovy are dominated by its GLP1 class effects and includes both common, generally manageable GI symptoms and less frequent but clinically significant risks
Downie says to go in with a try before you buy mindset, with specific asks in mind: Can I see before-and-after pictures to get an idea of the range of tones you are treating
That perspective shouldnt be forgotten.
