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Some studies have reported the beneficial effects of incretin mimetics as an effective therapy for hyperphagia and obesity in PWS, considering its potential effects on ghrelin suppression, central appetite suppression (through its action on pro-opiomelanocortin POMC/CART neurons and cocaine- and amphetamine-regulated transcripts in the arcuate nucleus (195),), increased energy expenditure (EE) and stimulation of insulin secretion, which could counterbalance the hypoinsulinemia reported in PWS (196200)
Two patients (18%) developed alopecia at 6-10 months
In practice, the longer GLP-1 medications are used, the more opportunity there is to stabilise weight and reduce the risk of regain
Aguayo LG, Espinoza F, Kunos G, Satin LS
What to expect in your first month on Mounjaro During your first month on Mounjaro, youll likely experience several changes as your body adjusts to the medication: Week 1-2: Initial impact on appetite usually begin within 24-48 hours of your first injection You may notice reduced hunger and food cravings Youll likely feel fuller quicker Side effects like nausea or fatigue may appear (more on managing these below) Week 3-4: Weight loss typically becomes noticeable (2-4% of starting weight) Some people experience the medications effects wearing off 4-5 days after injection Hunger levels become more consistent Side effects generally start to decrease The SURMOUNT-1 trial data 1 shows that while the average weight loss is 2-4% in the first month, the range varies considerably
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