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A head-to-head clinical trial (SURMOUNT-5) published in The New England Journal of Medicine in 2025 also demonstrated the superiority of tirzepatide over semaglutide

The 12mg cohort achieved the highest mean body weight reduction at -24.2% exceeding all published results for semaglutide (approximately -16% in the STEP trials) and tirzepatide (approximately -22.5% in SURMOUNT-1) at their respective maximum doses

Are GLP 1 & GIP Based Therapies for everyone who wants to lose weight

Studies using monoclonal antibodies against GLP-1R revealed that it is mainly present in the vasculature of the kidney (Pyke et al., 2014

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The decision is individualized between you, your surgeon, your anesthesiologist, and your prescribing physician, so be fully open about your medication at your consultation