Gallbladder and biliary events: As a class effect observed with GLP-1-based therapies, there is a potential risk of gallstones and related biliary complications
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At the same time, it was found that polysaccharides, diosgenin, and taxifolin are the metabolites of Chinese yam ( Bacteroides thetaiotaomicron and Paramuribaculum intestinale ( Diosgenin, an active metabolite of Chinese yam, can modulate immunoregulation involving CD4 and CD8 cells, upregulate IFN- levels, and increase the levels of Lactobacillus , Sutterella , and Bacteroides ( Prevotella , Odoribacter , Mucispirillum and Veillonella ( Clostridia (Yan et al., 2023)
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In human case reports, exposure to SGLT2 inhibitors was associated with a higher than expected incidence of congenital malformations, such as hydrocephalus, encephalocele, renal aplasia and esophageal atresia, as well as miscarriages
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