tirzepatide surpass trials Efficacy and safety of monotherapy compared with dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono): a double-blind, multicentre, randomised, phase 3 trial Reduction of prevalence of patients

Increased myocardial glycolysis leads to enhanced O-GlcNAcylation-mediated mitochondrial dysfunction and structural damage 47

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These effects are often most prominent during initial dosing and after dose escalation, and may decrease with continued treatment or provider-directed dose adjustment

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At the highest doses tested, the combined targeted therapy also decreased body weight

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