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It is also a substrate for enzymes like sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate gene expression, DNA repair, and cellular stress responses

Neurology 1996, 46: 465-469

Your adrenal glands produce more cortisol, the stress-fighting hormone, to deal with the effects of stress

doi:10.1073/pnas.1801609115 Freo U, Brugnatelli V, Turco F, Zanette G

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