8.5 Geriatric Use JANUMET XR In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant disease or other drug therapy and the higher risk of lactic acidosis
However, in some tumors, such as pancreatic cancer and melanoma, additional glutamine can inhibit the proliferation of tumor cells, and this mechanism is closely related to the regulation of the immune microenvironment
Although there were no statistically significant differences between the treatment groups for adverse events, numbers of subjects reporting adverse events, serious adverse events, treatment-related adverse events, and severe adverse events were all greater in the treatment group (Table 12)
However, the timing can affect how you experience side effects
Chilton, W., & Charchar, F
27 Furthermore, compromised mitochondrial beta-oxidation leads to alternative peroxisomal and cytochrome oxidation pathways for fatty acids, producing excess free radicals