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Many commenters recommended alternative effective dates, ranging from 60 days to 2 years beyond our proposed effective date of January 1, 2026, that they considered more reasonable

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Oxidative stress, which results from the imbalance between the production and neutralization of ROS, is also reported to be involved in a large number of pathological states, such as Alzheimers disease [30], Parkinsons disease [31], atherosclerosis [32], heart failure [33], myocardial infarction [34], and hepatic encephalopathy [35]

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