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New England Journal of Medicine, 336(3), 186-195

Andersen, S

However, the administered NA dose was based on efficiency in hypercholesterolemia studies, therefore, an optimal NA dose for mitochondrial myopathy has to be determined, especially considering that another study found an association between metabolites of excess NA, 2PY, and 4PY, and cardiovascular disease (CVD) 245

This dosage aligns with published research protocols and sits well within established safety margins

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