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No formal adjustments will be undertaken to constrain the overall type I error associated with the secondary and exploratory analyses
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Within oligodendrocytes, aspartate serves as an amino donor for aspartate transaminase (AST) which transfers the nitrogen to 2-oxoglutarate (-ketoglutarate) generating glutamate and oxaloacetate (OAA)
Oral glutathione and NAC have decades of safety data