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a complex suite of biochemical and biophysical changes that prime spermatozoa for interaction with the cumulus oophorus and zona pellucida (ZP) surrounding the ovulated oocyte ( Figure 2 )

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what differs is how and when they are absorbed in the body

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The most straightforward should be the reaction with acid chlorides since they are the most reactive carboxylic acid derivatives, and amines are good nucleophiles too

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