These enzymes have demonstrated potential therapeutic value in mitigating lipid peroxidation and ferroptosis (Liang et al., 2023)
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Sachinidis A, Nikolic D, Stoian AP et al (2020) Cardiovascular outcomes trials with incretin-based medications: a critical review of data available on GLP-1 receptor agonists and DPP-4 inhibitors
This creates a feedback loop where sensitivity breeds more sensitivity
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Separate signaling cascades can also determine an increase of cytosolic Ca 2+ which includes the phosphorylation of PKA after GLP-1 receptor activation, the increase of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) levels and the mobilization of Ca 2+ stores [33, 36]