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SB: Data curation, Writing original draft, Writing review & editing, Conceptualization

STRUCTURE OF THE GH PROMOTER Because of their origin from an ancestral GH-like gene, all five genes in the GH genomic locus share 95% sequence identity including their promoters (282): proximal elements in the promoter bind Pit-1/GHF-1 (283-286)

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These medications also require caution in people with a personal or family history of medullary thyroid cancer or MEN2, history of pancreatitis, significant gallbladder disease, severe gastroparesis, or active eating disorder concerns

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While effects specifically on endogenous GLP-1 require further research, the overall metabolic benefits of exercise are well-established