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Elevated ferrous ions and iron homeostasis imbalances can further increase ROS through the Fenton reaction, also contributing to ferroptosis

Ann N Y Acad Sci.2004;1033(1):108-116

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Clinical Implications and Remaining Gaps Modeling studies suggest that the cumulative impact of combination therapy may be substantial, with meaningful gains in cardiovascular and kidney event-free survival when implemented early in high-risk populations [38]

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