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Thus, compared to other amino acid incorporation events, Sec incorporation may be less efficient, in part, due to limitations in the availability of cofactors involved in normal Sec-translation and the relative efficiency of normal translation termination events that occur at UGA stop codons

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Miller J, Silverstein J, Shuster J, Driscoll DJ, Wagner M : Short-term effects of growth hormone on sleep abnormalities in Prader-Willi syndrome

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Below-projection efficacy: REDEFINE 1s ~22.7% missed the higher figure Novo Nordisk had signaled, tempering best-in-class framing an honest data point, not an adverse event