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Additionally, B12 is involved in the metabolism of homocysteine, an amino acid that, when elevated, can increase the risk of heart disease

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Based on this mechanism of action alone, it is automatically assumed that these peptides contribute to tumor growth (or are at least correlated with this outcome)

The Phase 2 Weight-Loss Signal In the published Phase 2 dose-escalation trial (NCT04881760, N=338, 24 weeks), participants receiving retatrutide 12 mg achieved a mean body weight reduction of 17.5% versus 1.6% with placebo (P 271 nmol/L) confirms functional tissue deficiency even when serum B12 appears borderline normal

DOI: 10.1056/NEJMoa2032183 Marso SP, et al