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And the mRNA expression levels of SIRT1, PGC-1, and PEPCK in the liver of the mice were significantly increased

The Bacterial Contamination Theory proposes that such dysbiosis introduces lipopolysaccharides (LPS) into the uterine environment, which activate pattern recognition receptors through binding to the TLR4/MD2 complex, triggering MyD88-dependent signaling that phosphorylates IB and liberates NF-B for nuclear translocation, ultimately inducing chronic inflammatory cascades and further exacerbating endometriotic pathology

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