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As an iron-dependent form of cell death, ferroptosis involves three major mechanistic pathways, all contributing to RA pathogenesis

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New England Journal of Medicine (2025) The REDEFINE 1 Phase 3 trial was a landmark 68-week, double-blind, randomized study comparing CagriSema (cagrilintide 2.4 mg plus semaglutide 2.4 mg) with semaglutide alone, cagrilintide alone, and placebo in 3,417 adults with obesity or overweight without diabetes

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Within these comparatively autonomous mechanisms governing cell death, the introduction of Fer-1 substantially elevated cell survival rates, indicative of the effective suppression of OGD induced ferroptosis