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An updated meta-analysis of independently adjudicated cardiovascular events from 19 double-blind randomized trials (n=9,459 patients) showed a lower composite event rate for linagliptin (13.4 per 1,000 patient years) versus comparators (18.9 per 1,000 patient years) for a hazard ratio of 0.78 (95% CI, 0.551.12

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Acknowledgements This paper was funded by grants from the National Natural Science Foundation of China (82070588, 82370577), National Key R&D Program of China (2023YFA1800801)

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Bucklew lost 25 pounds in six months and reportedly gained more energy