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Science translational medicine 4, 141190

Across the PIONEER trials around 1523% of patients experienced nausea with orally administered semaglutide 14 mg, and approximately 715% of patients on 14 mg orally administered semaglutide discontinued the trial

Fatigue was assessed using the 13-item Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale (0-52, with lower scores representing higher levels of fatigue)

Therefore, spacing doses appropriately can help mitigate these effects

[29] It has also been linked to optic nerve atrophy and neuritis