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We wanted to set the record straight in terms of what we think, in terms of the science that we know, in terms the experience that we as OB-GYN clinicians have, she said

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3,11,12,30 DPP-4 inhibitors have not been shown to cause weight gain or hypoglycemia unless used in combination with other antihyperglycemic agents, such as insulin or sulfonylureas

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In MASLD, reduced SIRT1 activity leads to hyperacetylation and stabilization of PLIN2 and PLIN3, effectively locking lipid droplets and impairing lipophagic clearance, exacerbating triglyceride accumulation