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Review adherence, technique, storage ensuring proper execution before assuming ineffectiveness

High-dose use While trials have tested up to 1200mg/day (even as high as 2400mg/day) and illustrated safety, some report higher rates of gastrointestinal side effects, dizziness, and skin reactions at these levels.14 28 38 Additionally, these higher doses are often short-term (35 weeks) and used under clinical supervision

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Nutrients , 11 (10), 2412.

In the hippocampus, KCC2 mRNA levels are closely linked to GABA function, with overexpression of KCC2 shifting GABAs action from excitatory to inhibitory, which helps maintaining the E/I balance (Ben-Ari, 2002)

Iron-dependent cell death relies on lipid peroxidation of iron, ultimately leading to programmed cell death