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While the study missed its primary endpoint it reported a reduction in heavy alcohol consumption among participants with obesity (Klausen Jensen Mller)

By focusing on these three ST models rather than all nine possible combinations, we retain interpretability and improve precision

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Coconut milk is not included for most U.C

Specifically, 2.12 mM GDC increased calcitonin permeability in Caco-2 monolayers by 10.66-fold and decreased TEER by 4.57-fold (52), whilst 0.5 mM GDC increased [ 14 C]-mannitol apparent permeability (Papp) by 3-fold and transiently decreased TEER by 2.5-fold, without reducing cell viability (MTS, CellTox Green assay, Caspase 3/7) (44)