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Description

As a result, significant efforts are being made to develop long-acting GLP-1R agonists, through the substitution of a susceptible amino acid in GLP-1 into a mutant to confer resistance to DPP-IV degradation 12 and the significantly prolonging of GLP-1 half-life via the virtue of the neonatal Fc receptor (FcRn) recycling mechanism through binding to IgG-Fc 13 or human serum albumin (HSA) 14

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The elimination half-life of L-theanine is relatively short, approximately 65 minutes

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Iorga RA, Bacalbasa N, Carsote M, Bratu OG, Stanescu AMA, Bungau S, Pantis C, Diaconu CC (2020) Metabolic and cardiovascular benefits of GLP-1 agonists, besides the hypoglycemic effect (Review)

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