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Research has demonstrated that GHK-Cu may influence gene expression related to extracellular matrix production, including collagen, elastin, decorin, and glycosaminoglycan synthesis

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[4] Mechanistically, the GHRH component recruits and primes the releasable pool of GH inside the somatotroph, while the ghrelin-receptor component triggers release and blunts the somatostatin brake that would otherwise cap the pulse