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Despite the different brand names and method of application, all of these three medications are based on the active ingredient semaglutide, which works by mimicking hormones called incretins that help control insulin production after meals

The characteristics of study participants are presented in Table 1 and the enrollment algorithm is presented in Figure 1

This is particularly concerning for older adults, postmenopausal women, and anyone with existing osteoporosis risk factors

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These predispositions do not determine outcomes but may help contextualize why some patients require higher doses or longer titration windows for adequate effect

Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, doubleblind, placebo and active controlled, doseranging, phase 2 trial