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In some embodiments, the steady state concentration of an active agent released from a controlled-release otic formulation described herein is from about 20 to about 50 times the steady state concentration of an active agent released from a formulation that is not a controlled-release otic formulation

This hormonal shift leads to breakouts 1week to a few days before the period

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The majority of glutamine production occurs in muscle tissue, accounting for about 90% of all glutamine synthesized

By bypassing the digestive system, this method helps reduce ingredient and peptide loss, it also allows the body to access peptides more efficiently than tablets, capsules or topical products

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