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Connective tissues include: Tendons Ligaments Fascia Cartilage support structures Skin matrix Joint-supporting tissues These tissues heal slowly because they often have limited blood supply

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In MM, SPRED1 loss rarely co-occurs with BRAF mutations, NRAS mutations, or NF1 inactivation mutations ( NF1 , around 30% of MM cases with SPRED1 inactivation simultaneously exhibit KIT alterations, suggesting that SPRED1 inactivation may be in collaboration with other oncogenic events to stimulate tumor development (100)

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These medications improve insulin function and glucose control, which may help prevent or manage Type 2 diabetes

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