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The naturally occurring FOXO4 protein appears to regulate the levels of proteasome enzymes, but it does not necessarily help reduce damaged cells

International Journal of Biological Macromolecules , 140 , 343349

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Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells

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To address this limitation, we generated a mutant library through UV radiation and identified mutants with enhanced glutathione levels using an acrolein resistancemediated screening approach