Reasons for exclusion were: 1) the paper did not contain any relevant data
Chronic exposure to NPs has been linked to several diseases in animals in several studies, including irreversible testicular damage, lung damage, hepatotoxicity, neurotoxicity, and renal toxicity 15,16,17
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Because baseline weights were lower in the mazdutide trials, the absolute number of pounds lost differs from the heavier baseline cohorts in the global SURMOUNT trials, making direct cross-trial declarations of superiority scientifically invalid
Tirzepatide follows a structured dose-escalation schedule, starting at 2.5 mg once weekly and increasing every 4 weeks (to 5 mg, 7.5 mg, 10 mg, 12.5 mg, and up to 15 mg) for both Mounjaro and Zepbound